Mouse Button 6+

Hello! I just purchased a Naga Pro, and I intend to mainly use the 6-buttons panel. I was wondering if there was a possibility to make a Synapse Profile where the six thumb buttons would be mapped to Mouse Button 4 through Mouse Button 10.
My goal is to avoid having to make a new Synapse profile for every game I play. Instead, I would go in-game and map the buttons to in-game functions.