I recently had a very annoying experience with Synapse/ Chroma. Ever since the new Overwatch update came out today (3/20/18), whenever I would start Overwatch from the b.net launcher, a black screen would come up and the application would immediately close. It took 2 live chats with Blizzard Support Agents before we figured out that it was Razer Synapse/ Chroma that was somehow interfering with Overwatch (but no other Blizzard Games). I don't know if the issue was Synapse not being updated or the fact that the app interfered with Overwatch altogether. Either way, it took me several hours to get this sorted out :/.