Do the side buttons on the Viper V2 Pro work on the latest macOS?

I do not use the driver any more. I now use Karabiner-Elements (by pqrs) this is for macOS 11 and higher. I use the Element Viewer to find out the keys on the Orbweaver and then create a profile then ReMap the keys to the game that I am using (WoW, ESO,...). Karabiner-Elements has a menu in the Menu bar similar to Razer where you can easily choose your Profile for your game.

Karabiner-Elements will remap keys/buttons on most input devices (even Wintel only ones) so you are no longer restricted to Mac only devices.

There is also the Koolertron One Handed Macro Mechanical Keyboard (or look-alike) from Amazon or Ebay. It has a Mac app that you can use to assign keys and macros.

Update: I have now purchased a Tartarus Pro and it works with Kerabiner-Elements. I can have multiple profiles (for different Games, etc). The only thing it does not do is control the colour - I use OperRGB for that.

Actually this is more flexible than the Razer driver and works with macOS 11 or higher (including  Ventura) and unlike the Razer driver it is actively maintained.