Profile issues

Hi. I have a problem with a Mouse Profile I set up. I set up a normal profile: When I start playing LoL the profile automatically change, but nothing happen, don't change. I think the problem is that the default .exe provide by Synapse 3 is incorrect (LeagueClient.exe). So I try to set up the correct .exe (League of Legends.exe), but when I press 'save' go back to the old location (LeagueClient.exe). * I tried to 'solve' that problem setting up a Global Shortcut to change profiles with my keyboard, but the entire Global Shortcuts features don't work (If you have solution for this too, I will be grateful). :frown_::frown_::frown_: