I tried repairing and reinstalling Synapse, but it still didn't help.It still doesn't work correctly.

It seems to me that the connection between the game and Synapse is lost a second after pressing the mouse button because without Synapse there is no such problem.

The problem is that the WASD and TAB buttons work properly, the inventory panel window and the map open properly, but skills from the skill panel cannot be used with Synapse enabled.

Then strange things happen:
Firstly, in the first second, after pressing the mouse button in the game window, skills can be used, but after a second, the buttons stop working. You have to click on the mouse button to use a skill from the skill panel every time before use the skill.

Secondly:
After using the skill, the skill goes into cooldown, during the cooldown the Tartarus buttons work, but when the skill is ready for use, it cannot be used again until you press the button on the mouse.
With Synapse turned off, everything works fine, you don’t have to click the mouse button every time.