tldr; Install Chroma Beta, use link in Chroma Beta to download The new Razor synapse (not 3), uninstall Chroma Beta
I could not get Synapse 3 to switch profiles with applications (Windows 11, never tried on 10)
I uninstalled it and downloaded the Chroma Beta App. In that app is a link to download Synapse Beta. I could not find the link for that on the website that guides you to Synapse 3 instead.
So I used Chroma Beta to download Synapse beta and then it wouldn’t even change colors through either app. So I uninstalled Chroma Beta, leaving Synapse beta installed. It works perfectly this way. I only have 1 device (Tartarus V2) so I don’t know anything about anything other than getting it to switch profiles and working as I intended.