Naga V2 Hyperspeed is Synapse 3 enabled. Synapse 3 is not available on mac os.

You can try 3rd party app like Razer macOS, but not all functions may be available: https://github.com/1kc/razer-macos

there’s a mac osx software SteerMouse that is much easier than e.g. BetterTouchTool and able to program all the buttons on my wired Razer Naga Trinity (also to customize the wheel and cursor speed; you can also program different profiles for different applications), it won’t however control RGB if that’s what you’re after as well. It is truly a pity Razer gave up on osx as there’s no other mouse with as many buttons that would be designed for mac. I’m not a gamer but I can’t live without wheel scrolling and multiple keyboard shortcuts and macros, so much so that there’s one Razer Naga connected to each of my 4 computers. Shame on you, Razer! :D

After installation you’ll find SteerMouse at the bottom of System Settings app.

I also purchased this mouse to find out it is not supported on Mac OS, what a let down.