I can provide modre data if necessary. Thanks for offering up your hardware to MSi.

Newer MSi motherbords seem to be the common thread here.

I had no issues using the mouse dock pro on an older MSi X99 motherboard running W10.

If it isn’t MSi USB drivers, then it’s a Razer f/w problem.

All of motherboard make dock pro malfunction are intel 12th chipset or higher like b660 z690 z790.

When i boot on computer, of course mouse would not be recognized, but recently i notice somethings interesting: When i booting to bios , the brightness of the LED on dock will be much darker than normaly, seems like to its insufficient power supply(low voltage). Then wait 20 seconds or more, the brightness will become nomarly and mouse can recognized on bios in the same time.  But it cant work when i booting to Windows.

I think maybe those circuits or boot logics of USB Powersupply are different between MSI 12th motherboard and other brands.

Okay so I had this same issue after getting a new mother board and it is an MSI mother board. Its the MSI Z790 gaming board. I have had the issue where it does not recognize the dock when it first boots. What fixed it for me is enabling USB fast boot in the MSI center application. Hope this helps! 

I have the same problem.

The same thing happens with Ryzen 5600X on MSI MPG B550 GAMING PLUS.

I have tried reinstalling Synapse, driver cleaners, etc. to no avail.

When this problem occurs, it will not return to normal unless the USB connector is plugged back in, and it will be accompanied by problems such as Synapse not recognizing the mouse or not being able to change the profile.

It's obviously Razer's fault, but I still can't hide my disappointment that they haven't done anything about it.

ive done this multiple times and the issue is still there

i hop you all email razer about this issue like i have. i even had them send me a new one cause we deemed it a hardware issue, but i got my new one and its still doing it……. RAZER PLEASEEEEEEEEE FIX THIS!!!!!! make a firmware update

I found this interesting. I also have an MSI Z690 board and have been having this issue like crazy. I went into the MSI Center application and I have loaded the “Devices Speed Up” option and activated the “Speed up USB” option. It seems that it has fixed this issue for me. My Basilisk V3 Pro is now connecting and I’ve not had this issue since I’ve activated this setting. I will report back here if anything changes.

After seeing this I decided to try it myself. Also a z790 board, Carbon WIFI 2 with a 13900k. Sure enough, when i shutdown the PC the dock stays lit and it works on boot. I think the reason is that although windows has a setting to keep USB ports powered, I dont think it is full power or full signal. The MSI Center feature seems to turn this on so it not only charges, but has full power and recognizability. Thanks Stormcloud!

I had to RMA my MSi Z790 Ace due to a USB Overcurrent fault.

I replaced it with an MSi Z790 Godlike Max.

Initially, I thought this problem might have been tied to the Ace, but it’s still happening on the Godlike Max.

I’ve been trying  to solve this for over a year. I’ll likely just move away from the Mouse Dock Pro once and for all.

Same problem here, also with a z790. I also have a Razer RGB controller and I was getting weird lighting situations where one and a half fans would either be completely off or out of sync with the rest of the system. The only app I have installed in MSI Center is Mystic Light. I didn’t see an option for USB fast boot and I didn’t want to install “Devices Speed Up” but I remembered a similar setting in my BIOS.

So I went to BIOS and “Windows USB fast boot” was enabled. Above that setting is an option for “MSI USB fast boot” that was disabled. These options are mutually exclusive. I enabled “MSI USB fast boot” and this seems to have fixed the mouse dock pro and the RGB controller issue.

Hello guys! MSi z690 here and my story.
So what i did:

1. Uninstall synapse 3
2. Download & run this tool: https://rzr.to/Tf53xj to remove any razer drivers
3. Install the Synapse 4 (https://www.razer.com/synapse-4) 

Still no problem few days by. I’ll be back if any bad news appear.

No way!!! I really hope this works. I'll try it.

Have done this off the back off your suggestion.  It appears the mouse dock pro now connects each time the PC boots (only been using it for half hour) which is already an improvement on before. 

The move to Synapse 4 has created a new issue, which is the Chroma RGB controller connected using one of the USB headers, no longer drives all my LED’s components correctly.  I have  been back through and set it all up again with the correct LED count (the auto count never works properly).  The software also doesn’t control the motherboard LEDs properly even when giving it control over MSI Mysticlight using the switch in MSI.  

Why are Razer so bad at this? They have quite the nack for breaking things that didn’t need fixing. 

It's cause they are a Chinese company. 

I have followed the steps and will update in about a month if everything keeps working on boot now. So far so good but the issue for me is intermittent so will need some time to see.

Fixed the chroma controller issue, I had to remove the software and drivers again, reboot, power down, unplugged the controller from the usb header, booted up, run the driver cleaner again, shut down, reconnect the controller to the header, then install Synapse 4, reboot, then retrain the controller for the configuration of RGBs. This seems to have done the trick.   

Its a process and quality control thing, I think this happens more and more with any technology company, the customer becomes the tester and the company doesn't value the customer highly so problems do not get fixed. 

If Windows 11,
What seems to be the problem: storage of kernel state is somehow interfering somehow with dock pro connection on kernel state load. Try restarting instead of shut down, does the problem still occur? If yes, then it may be something else; If no, see below.

What fixed for me, disable kernel state saving: control panel → power options → choose what the power buttons do → change settings that are currently unavailable (need admin priv) → uncheck fast startup.

This will force a kernel restart every power off.

I have my power scheme set to ultimate performance, I do not have a fast start up option. I have tried from the commandline using powercfg -h off and verified by looking for the registry key “HiberbootEnabled” and making sure it was value 0

It still didn’t work, the now very familiar “device descriptor request failed” message in device manager. 

It's been 1.5 years since I purchased the docking station and mouse. During this time, Razer did NOT solve the problem with firmware updates. The only way is the MSI fast startup mode in the motherboard BIOS. 

Applause gentlemen

It's been 1.5 years since I purchased the docking station and mouse. During this time, Razer did NOT solve the problem with firmware updates. The only way is the MSI fast startup mode in the motherboard BIOS. 

Applause gentlemen

Can you elaborate, only way is to enable or disable? What does the fast startup do and how does enabling/disabling affect usb?

It's been 1.5 years since I purchased the docking station and mouse. During this time, Razer did NOT solve the problem with firmware updates. The only way is the MSI fast startup mode in the motherboard BIOS. 

Applause gentlemen

быстрая загрузка bios не проверяет usb порты, а сразу грузит ос 

It's been 1.5 years since I purchased the docking station and mouse. During this time, Razer did NOT solve the problem with firmware updates. The only way is the MSI fast startup mode in the motherboard BIOS. 

Applause gentlemen

Still doesn't explain why it would work, but I will give it a go anyway.